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Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLC.
Moro, Massimo; Caiola, Elisa; Ganzinelli, Monica; Zulato, Elisabetta; Rulli, Eliana; Marabese, Mirko; Centonze, Giovanni; Busico, Adele; Pastorino, Ugo; de Braud, Filippo G; Vernieri, Claudio; Simbolo, Michele; Bria, Emilio; Scarpa, Aldo; Indraccolo, Stefano; Broggini, Massimo; Sozzi, Gabriella; Garassino, Marina Chiara.
Affiliation
  • Moro M; Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Caiola E; IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
  • Ganzinelli M; Thoracic Oncology, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Zulato E; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padova, Italy.
  • Rulli E; IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
  • Marabese M; IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
  • Centonze G; Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Busico A; Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Pastorino U; Thoracic Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • de Braud FG; Thoracic Oncology, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Vernieri C; Thoracic Oncology, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Milan, Italy.
  • Simbolo M; ARC-Net Research Centre and Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
  • Bria E; U.O.C. Oncologia Medica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Scarpa A; ARC-Net Research Centre and Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
  • Indraccolo S; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padova, Italy.
  • Broggini M; IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
  • Sozzi G; Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address: gabriella.sozzi@istitutotumori.mi.it.
  • Garassino MC; Thoracic Oncology, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
J Thorac Oncol ; 13(11): 1692-1704, 2018 11.
Article in En | MEDLINE | ID: mdl-30149143
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Proto-Oncogene Proteins p21(ras) / Cisplatin / Protein Serine-Threonine Kinases / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms / Metformin Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: J Thorac Oncol Year: 2018 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Proto-Oncogene Proteins p21(ras) / Cisplatin / Protein Serine-Threonine Kinases / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms / Metformin Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: J Thorac Oncol Year: 2018 Document type: Article Affiliation country: Country of publication: