Structural characterization and immune regulation of a novel polysaccharide from Maerkang Lactarius deliciosus Gray.
Int J Mol Med
; 44(2): 713-724, 2019 Aug.
Article
in En
| MEDLINE
| ID: mdl-31173162
ABSTRACT
The present study investigated the structural characterization and immune regulation of a novel polysaccharide from Maerkang Lactarius deliciosus Gray. Chemical methods, high performance gel permeation chromatography, fourier transform infrared spectroscopy, nuclear magnetic resonance spectrum and gas chromatographymass spectrometry were used to characterize the polysaccharide structure. The immunomodulatory abilities of the Maerkang L. deliciosus Gray polysaccharide (LDGM) were also investigated. LDGM was primarily composed of ßDglucose and αDlyxose with the ratio of 21. The possible structure of LDGM had a backbone of 1,6linkedßDglucose and 1,4,6linkedßDglucose, with branches primarily composed of one (1â4)linkedαDlyxose residue. The immunoregulatory activity results demonstrated that LDGM promoted the proliferation and phagocytosis of macrophages, and induced cytokine release. LDGM also promoted the proliferation of B cells by affecting the G0/G1, S and G2/M phases. The present study introduced LDGM as a valuable source with unique immunoregulatory properties.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Basidiomycota
/
Fungal Polysaccharides
/
Immunologic Factors
Limits:
Animals
Language:
En
Journal:
Int J Mol Med
Journal subject:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Year:
2019
Document type:
Article
Publication country:
GR
/
GRECIA
/
GREECE
/
GRÉCIA