Your browser doesn't support javascript.
loading
Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
Mullarky, Edouard; Xu, Jiayi; Robin, Anita D; Huggins, David J; Jennings, Andy; Noguchi, Naoyoshi; Olland, Andrea; Lakshminarasimhan, Damodharan; Miller, Michael; Tomita, Daisuke; Michino, Mayako; Su, Taojunfeng; Zhang, Guoan; Stamford, Andrew W; Meinke, Peter T; Kargman, Stacia; Cantley, Lewis C.
Affiliation
  • Mullarky E; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, United States; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, United States. Electronic address: edm2015@med.cornell.edu.
  • Xu J; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY 10021, United States.
  • Robin AD; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, United States; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, United States.
  • Huggins DJ; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY 10021, United States; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, United States.
  • Jennings A; Andy Jennings Consulting, LLC, United States.
  • Noguchi N; Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd., Shonan Research Center, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Olland A; Xtal Biostructures, 12 Michigan Drive, Natick, MA 01760, United States.
  • Lakshminarasimhan D; Xtal Biostructures, 12 Michigan Drive, Natick, MA 01760, United States.
  • Miller M; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY 10021, United States.
  • Tomita D; Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd., Shonan Research Center, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Michino M; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY 10021, United States.
  • Su T; Proteomics and Metabolomics Core Facility, Weill Cornell Medicine, New York, NY 10021, United States.
  • Zhang G; Proteomics and Metabolomics Core Facility, Weill Cornell Medicine, New York, NY 10021, United States.
  • Stamford AW; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY 10021, United States.
  • Meinke PT; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY 10021, United States.
  • Kargman S; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, NY 10021, United States.
  • Cantley LC; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, United States; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, United States. Electronic address: lcantley@med.cornell.edu.
Bioorg Med Chem Lett ; 29(17): 2503-2510, 2019 09 01.
Article in En | MEDLINE | ID: mdl-31327531
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / Enzyme Inhibitors / Phosphoglycerate Dehydrogenase / Amides / Indoles Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / Enzyme Inhibitors / Phosphoglycerate Dehydrogenase / Amides / Indoles Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: