Live cell imaging of macrophage/bacterium interaction demonstrates cell lysis induced by Corynebacterium diphtheriae and Corynebacterium ulcerans.
BMC Res Notes
; 12(1): 695, 2019 Oct 25.
Article
in En
| MEDLINE
| ID: mdl-31653227
ABSTRACT
OBJECTIVES:
In frame of a study to characterize the interaction of human macrophage-like cells with pathogenic corynebacteria, Corynebacterium diphtheriae and Corynebacterium ulcerans, live cell imaging experiments were carried out and time lapse fluorescence microscopy videos were generated, which are presented here. DATA DESCRIPTION The time lapse fluorescence microscopy data revealed new insights in the interaction of corynebacteria with human macrophage-like THP-1 cells. In contrast to uninfected cells and infections with non-pathogenic C. glutamicum used as a control, pathogenic C. diphtheriae and C. ulcerans showed highly detrimental effects towards human cells and induction of cell death of macrophages.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Corynebacterium
/
Corynebacterium diphtheriae
/
Time-Lapse Imaging
/
Macrophages
/
Microscopy, Fluorescence
Limits:
Humans
Language:
En
Journal:
BMC Res Notes
Year:
2019
Document type:
Article
Affiliation country: