Robust alginate/hyaluronic acid thiol-yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering.
Biomater Sci
; 8(1): 405-412, 2020 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-31729512
ABSTRACT
Hydrogels based on hyaluronic acid (HA) exhibit great potential as tissue engineering (TE) scaffolds as a consequence of their unique biological features. Herein, we examine how the advantages of two natural polymers (i.e. HA and alginate) are combined with the efficiency and rapid nature of the thiol-yne click chemistry reaction to obtain biocompatible matrices with tailored properties. Our injectable click-hydrogels revealed excellent mechanical performance, long-term stability, high cytocompatibility and adequate stiffness for the targeted application. This simple approach yielded HA hydrogels with characteristics that make them suitable for applications as 3D scaffolds to support and promote soft tissue regeneration.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfhydryl Compounds
/
Hydrogels
/
Tissue Engineering
/
Alginates
/
Alkynes
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Tissue Scaffolds
/
Hyaluronic Acid
Limits:
Humans
Language:
En
Journal:
Biomater Sci
Year:
2020
Document type:
Article
Affiliation country: