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Celastrol augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats.
Saber, Sameh; Abd El-Kader, Eman M; Sharaf, Hossam; El-Shamy, Rewan; El-Saeed, Baraah; Mostafa, Asmaa; Ezzat, Dalia; Shata, Ahmed.
Affiliation
  • Saber S; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. Electronic address: sameh.mohamed@deltauniv.edu.eg.
  • Abd El-Kader EM; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
  • Sharaf H; Department of Clinical Pharmacy, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
  • El-Shamy R; Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
  • El-Saeed B; Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
  • Mostafa A; Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
  • Ezzat D; Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
  • Shata A; Department of Clinical pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
Toxicol Appl Pharmacol ; 400: 115075, 2020 08 01.
Article in En | MEDLINE | ID: mdl-32470352
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Sulfones / Triterpenes / Colitis / HSP90 Heat-Shock Proteins / NLR Family, Pyrin Domain-Containing 3 Protein / Heterocyclic Compounds, 4 or More Rings / Anti-Inflammatory Agents Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2020 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Sulfones / Triterpenes / Colitis / HSP90 Heat-Shock Proteins / NLR Family, Pyrin Domain-Containing 3 Protein / Heterocyclic Compounds, 4 or More Rings / Anti-Inflammatory Agents Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2020 Document type: Article Country of publication: