The Great Ormond Street Hospital immunoadsorption method for ABO-incompatible heart transplantation: a practical technique.
Perfusion
; 36(1): 34-37, 2021 01.
Article
in En
| MEDLINE
| ID: mdl-32493108
ABSTRACT
Traditionally, ABO-incompatible heart transplantation was accomplished using a plasma exchange technique to remove recipient plasma containing donor-incompatible anti-A/B isohaemagglutinins. However, this technique exposed patients to large volumes of allogeneic blood and blood products (up to three times the patient's circulating volume). In 2018, we published the first reported case of an ABO-incompatible heart transplant using an intraoperative immunoadsorption technique which minimises the exposure to blood products by specifically targeting anti-A/B isohaemagglutinins. We have subsequently used this technique in all children undergoing ABO-incompatible heart transplantation and become convinced of its efficacy in this population while observing no adverse effects. This article outlines the practical details required to perform the technique in order to avoid hyperacute rejection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Group Incompatibility
/
Heart Transplantation
Limits:
Child
/
Humans
Language:
En
Journal:
Perfusion
Journal subject:
CARDIOLOGIA
Year:
2021
Document type:
Article
Affiliation country: