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Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors.
Haider, Ahmed; Gobbi, Luca; Kretz, Julian; Ullmer, Christoph; Brink, Andreas; Honer, Michael; Woltering, Thomas J; Muri, Dieter; Iding, Hans; Bürkler, Markus; Binder, Martin; Bartelmus, Christian; Knuesel, Irene; Pacher, Pal; Herde, Adrienne Müller; Spinelli, Francesco; Ahmed, Hazem; Atz, Kenneth; Keller, Claudia; Weber, Markus; Schibli, Roger; Mu, Linjing; Grether, Uwe; Ametamey, Simon M.
Affiliation
  • Haider A; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
  • Gobbi L; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Kretz J; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Ullmer C; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Brink A; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Honer M; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Woltering TJ; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Muri D; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Iding H; Pharma Technical Development, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.
  • Bürkler M; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Binder M; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Bartelmus C; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Knuesel I; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Pacher P; Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute of Health/NIAAA, 5625 Fishers Lane, Rockville, 20852 Maryland, United States.
  • Herde AM; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
  • Spinelli F; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
  • Ahmed H; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
  • Atz K; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland.
  • Keller C; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
  • Weber M; Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland.
  • Schibli R; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
  • Mu L; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.
  • Grether U; Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
  • Ametamey SM; Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.
J Med Chem ; 63(18): 10287-10306, 2020 09 24.
Article in En | MEDLINE | ID: mdl-32787079
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Radiopharmaceuticals / Receptor, Cannabinoid, CB2 Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Radiopharmaceuticals / Receptor, Cannabinoid, CB2 Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Country of publication: