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Assessment of Clinical Drug-Drug Interactions of Elagolix, a Gonadotropin-Releasing Hormone Receptor Antagonist.
Polepally, Akshanth R; Ng, Juki W; Salem, Ahmed Hamed; Dufek, Matthew B; Parikh, Apurvasena; Carter, David C; Kamradt, Kent; Mostafa, Nael M; Shebley, Mohamad.
Affiliation
  • Polepally AR; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., Redwood City, California, USA.
  • Ng JW; Pharmaceutical Development, General Medicine, AbbVie Inc., North Chicago, Illinois, USA.
  • Salem AH; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.
  • Dufek MB; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.
  • Parikh A; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., Redwood City, California, USA.
  • Carter DC; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.
  • Kamradt K; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.
  • Mostafa NM; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.
  • Shebley M; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.
J Clin Pharmacol ; 60(12): 1606-1616, 2020 12.
Article in En | MEDLINE | ID: mdl-33045114
Subject(s)
Hydrocarbons, Fluorinated/administration & dosage; Hydrocarbons, Fluorinated/pharmacokinetics; Pyrimidines/administration & dosage; Pyrimidines/pharmacokinetics; Receptors, LHRH/antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily B, Member 1/agonists; ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism; Adult; Cytochrome P-450 CYP2B6/metabolism; Cytochrome P-450 CYP2B6 Inducers/administration & dosage; Cytochrome P-450 CYP2B6 Inducers/pharmacokinetics; Cytochrome P-450 CYP2C9 Inhibitors/administration & dosage; Cytochrome P-450 CYP2C9 Inhibitors/pharmacokinetics; Cytochrome P-450 CYP3A/metabolism; Cytochrome P-450 CYP3A Inducers/administration & dosage; Cytochrome P-450 CYP3A Inducers/pharmacokinetics; Cytochrome P-450 CYP3A Inhibitors/administration & dosage; Cytochrome P-450 CYP3A Inhibitors/pharmacokinetics; Drug Administration Schedule; Drug Interactions; Female; Healthy Volunteers; Humans; Hydrocarbons, Fluorinated/blood; Hydrocarbons, Fluorinated/pharmacology; Liver-Specific Organic Anion Transporter 1/antagonists & inhibitors; Liver-Specific Organic Anion Transporter 1/metabolism; Male; Middle Aged; Neoplasm Proteins/metabolism; Premenopause; Pyrimidines/blood; Pyrimidines/pharmacology; Solute Carrier Organic Anion Transporter Family Member 1B3/antagonists & inhibitors; Solute Carrier Organic Anion Transporter Family Member 1B3/metabolism; Young Adult
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Receptors, LHRH / Hydrocarbons, Fluorinated Type of study: Prognostic_studies Language: En Journal: J Clin Pharmacol Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Receptors, LHRH / Hydrocarbons, Fluorinated Type of study: Prognostic_studies Language: En Journal: J Clin Pharmacol Year: 2020 Document type: Article Affiliation country: Country of publication: