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Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.
Lemieux, Jacob E; Siddle, Katherine J; Shaw, Bennett M; Loreth, Christine; Schaffner, Stephen F; Gladden-Young, Adrianne; Adams, Gordon; Fink, Timelia; Tomkins-Tinch, Christopher H; Krasilnikova, Lydia A; DeRuff, Katherine C; Rudy, Melissa; Bauer, Matthew R; Lagerborg, Kim A; Normandin, Erica; Chapman, Sinéad B; Reilly, Steven K; Anahtar, Melis N; Lin, Aaron E; Carter, Amber; Myhrvold, Cameron; Kemball, Molly E; Chaluvadi, Sushma; Cusick, Caroline; Flowers, Katelyn; Neumann, Anna; Cerrato, Felecia; Farhat, Maha; Slater, Damien; Harris, Jason B; Branda, John A; Hooper, David; Gaeta, Jessie M; Baggett, Travis P; O'Connell, James; Gnirke, Andreas; Lieberman, Tami D; Philippakis, Anthony; Burns, Meagan; Brown, Catherine M; Luban, Jeremy; Ryan, Edward T; Turbett, Sarah E; LaRocque, Regina C; Hanage, William P; Gallagher, Glen R; Madoff, Lawrence C; Smole, Sandra; Pierce, Virginia M; Rosenberg, Eric.
Affiliation
  • Lemieux JE; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA. lemieux@broadinstitute.org pardis@broadinstitute.org bronwyn@broadinstitute.org.
  • Siddle KJ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
  • Shaw BM; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Loreth C; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Schaffner SF; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Gladden-Young A; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
  • Adams G; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Fink T; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Tomkins-Tinch CH; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Krasilnikova LA; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • DeRuff KC; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Rudy M; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Bauer MR; Massachusetts Department of Public Health, Boston, MA, USA.
  • Lagerborg KA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Normandin E; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Chapman SB; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Reilly SK; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Anahtar MN; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Lin AE; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Carter A; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Myhrvold C; Harvard Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.
  • Kemball ME; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Chaluvadi S; Harvard Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.
  • Cusick C; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Flowers K; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  • Neumann A; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Cerrato F; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Farhat M; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Slater D; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  • Harris JB; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Branda JA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Hooper D; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Gaeta JM; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Baggett TP; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • O'Connell J; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Gnirke A; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  • Lieberman TD; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Philippakis A; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Burns M; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Brown CM; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Luban J; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
  • Ryan ET; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  • Turbett SE; Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA, USA.
  • LaRocque RC; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
  • Hanage WP; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
  • Gallagher GR; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Madoff LC; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  • Smole S; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
  • Pierce VM; Institute for Research, Quality, and Policy in Homeless Health Care, Boston Health Care for the Homeless Program, Boston, MA, USA.
  • Rosenberg E; Section of General Internal Medicine, Boston University Medical Center, Boston, MA, USA.
Science ; 371(6529)2021 02 05.
Article in En | MEDLINE | ID: mdl-33303686
Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two superspreading events. One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, whereas other introductions into the facility had little effect. The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread. The two events also differed substantially in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events. Our results show how genomic epidemiology can help to understand the link between individual clusters and wider community spread.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phylogeny / Genome, Viral / SARS-CoV-2 / COVID-19 Type of study: Screening_studies Limits: Humans Country/Region as subject: America do norte Language: En Journal: Science Year: 2021 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phylogeny / Genome, Viral / SARS-CoV-2 / COVID-19 Type of study: Screening_studies Limits: Humans Country/Region as subject: America do norte Language: En Journal: Science Year: 2021 Document type: Article Country of publication: