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Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers.
Wolodko, Karolina; Castillo-Fernandez, Juan; Kelsey, Gavin; Galvão, António.
Affiliation
  • Wolodko K; Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of PAS, Tuwima 10, 10-748 Olsztyn, Poland.
  • Castillo-Fernandez J; Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.
  • Kelsey G; Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.
  • Galvão A; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK.
Int J Mol Sci ; 22(8)2021 Apr 20.
Article in En | MEDLINE | ID: mdl-33924072
ABSTRACT
The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Oogenesis / Signal Transduction / Cell Differentiation / Leptin / Ovarian Follicle / Obesity Type of study: Etiology_studies Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Oogenesis / Signal Transduction / Cell Differentiation / Leptin / Ovarian Follicle / Obesity Type of study: Etiology_studies Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: