Making decisions in missing person identification cases with low statistical power.
Forensic Sci Int Genet
; 54: 102519, 2021 09.
Article
in En
| MEDLINE
| ID: mdl-34139527
ABSTRACT
The present work proposes a general strategy for dealing with missing person identification cases through DNA-database search. Our main example is the identification of abducted children in the last civic-dictatorship of Argentina, known as the "Missing Grandchildren of Argentina". Particularly we focus on those pedigrees where few, or only distant relatives of the missing person are available, resulting in low statistical power. For such complex cases we provide a statistical method for selecting a likelihood ratio (LR) threshold for each pedigree based on error rates. Furthermore, we provide an open-source user friendly software for computing LR thresholds and error rates. The strategy described in the paper could be applied to other large-scale cases of DNA-based identification hampered by low statistical power.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA Fingerprinting
/
Databases, Nucleic Acid
Type of study:
Diagnostic_studies
Limits:
Child
/
Humans
Language:
En
Journal:
Forensic Sci Int Genet
Journal subject:
GENETICA
/
JURISPRUDENCIA
Year:
2021
Document type:
Article