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Experimental Comparison of the In Vivo Efficacy of Two Novel Anticancer Therapies.
Ruzanova, Vera S; Proskurina, Anastasia S; Ritter, Genrikh S; Efremov, Yaroslav R; Nikolin, Valeriy P; Popova, Nelly A; Naprimerov, Vasiliy A; Dolgova, Evgenia V; Potter, Ekaterina A; Kirikovich, Svetlana S; Levites, Evgeniy V; Mustafin, Zakhar S; Lashin, Sergey A; Burakova, Ekaterina A; Stetsenko, Dmitry A; Ostanin, Alexandr A; Chernykh, Elena R; Bogachev, Sergey S.
Affiliation
  • Ruzanova VS; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Proskurina AS; Novosibirsk State University, Novosibirsk, Russian Federation.
  • Ritter GS; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Efremov YR; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Nikolin VP; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Popova NA; Novosibirsk State University, Novosibirsk, Russian Federation.
  • Naprimerov VA; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Dolgova EV; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Potter EA; Novosibirsk State University, Novosibirsk, Russian Federation.
  • Kirikovich SS; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Levites EV; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Mustafin ZS; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Lashin SA; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Burakova EA; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Stetsenko DA; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Ostanin AA; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
  • Chernykh ER; Novosibirsk State University, Novosibirsk, Russian Federation.
  • Bogachev SS; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation.
Anticancer Res ; 41(7): 3371-3387, 2021 Jul.
Article in En | MEDLINE | ID: mdl-34230133
ABSTRACT
BACKGROUND/

AIM:

We compared the therapeutic efficacy of two recently developed experimental anticancer technologies 1) in situ vaccination based on local immunotherapy with CpG oligonucleotides and anti-OX40 antibodies to activate antitumor immune response and 2) "Karanahan" technology [from the Sanskrit karana ('source') + han ('to kill')] based on the combined injection of cyclophosphamide and double-stranded DNA to eradicate cancer stem cells. MATERIALS AND

METHODS:

The anticancer approaches were compared on three types of mouse malignant tumors with different grades of immunogenicity weakly immunogenic carcinoma Krebs-2, moderately immunogenic Lewis carcinoma, and highly immunogenic A20 В-cellular lymphoma.

RESULTS:

Our results indicated that in situ vaccination was the most effective against the highly immunogenic tumor А20. In addition, "Karanahan" demonstrated high efficiency in all types of tumors, regardless of their immunogenicity or size.

CONCLUSION:

"Karanahan" therapy showed higher efficacy relative to in situ vaccination with CpG oligonucleotides and anti-OX40 antibodies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunotherapy / Antineoplastic Agents Limits: Animals Language: En Journal: Anticancer Res Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunotherapy / Antineoplastic Agents Limits: Animals Language: En Journal: Anticancer Res Year: 2021 Document type: Article