[Research advances of prostaglandin E2 synthases and receptors in cardiovascular diseases].
Sheng Li Xue Bao
; 73(4): 665-680, 2021 Aug 25.
Article
in Zh
| MEDLINE
| ID: mdl-34405222
ABSTRACT
Prostaglandin E2 (PGE2) is an important lipid mediator derived from arachidonic acid. It is widely distributed in various tissues and involved in numerous physiological and pathophysiological processes. Based on the inhibition of inflammatory PGE2 production, non-steroidal anti-inflammatory drugs (NSAIDs) are considered as the most commonly used drugs to treat pain and inflammation. However, clinical trials have revealed that NSAIDs, especially cyclooxygenase-2 (COX-2) selective inhibitors, may predispose patients to a remarkably increased cardiovascular risk, including hypertension, myocardial infarction, and heart failure. This promotes scientists to develop new drugs to not only afford pain relief but also have cardiovascular efficacy. Microsomal prostaglandin E synthase-1 (mPGES-1), the key terminal enzyme catalyzing the synthesis of inflammatory PGE2, and the four PGE2 receptors (EP1-4) have gained more attention as the promising alternative drug targets for the development of novel NSAIDs. The role of mPGES-1 and EP receptors in cardiovascular diseases also has been widely studied. In this review, we highlight the most recent advances from our and other studies on the role of PGE2, particularly mPGES-1 and the four PGE2 receptors, in cardiovascular diseases.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
Limits:
Humans
Language:
Zh
Journal:
Sheng Li Xue Bao
Year:
2021
Document type:
Article
Affiliation country: