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Acetyl-CoA carboxylase 2 inhibition reduces skeletal muscle bioactive lipid content and attenuates progression of type 2 diabetes in Zucker diabetic fatty rats.
Takagi, Hiroyuki; Ikehara, Tatsuya; Hashimoto, Kumi; Tanimoto, Keiichi; Shimazaki, Atsuyuki; Kashiwagi, Yuto; Sakamoto, Shingo; Yukioka, Hideo.
Affiliation
  • Takagi H; Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan. Electronic address: hiroyuki.takagi@shionogi.co.jp.
  • Ikehara T; Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan.
  • Hashimoto K; Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan.
  • Tanimoto K; Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan.
  • Shimazaki A; Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan.
  • Kashiwagi Y; Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan.
  • Sakamoto S; Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan.
  • Yukioka H; Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan.
Eur J Pharmacol ; 910: 174451, 2021 Nov 05.
Article in En | MEDLINE | ID: mdl-34454928
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetyl-CoA Carboxylase / Muscle, Skeletal / Diabetes Mellitus, Type 2 / Alkenes / Enzyme Inhibitors / Lipid Metabolism Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2021 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetyl-CoA Carboxylase / Muscle, Skeletal / Diabetes Mellitus, Type 2 / Alkenes / Enzyme Inhibitors / Lipid Metabolism Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2021 Document type: Article Country of publication: