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Neuronal Induction of Bone-Fat Imbalance through Osteocyte Neuropeptide Y.
Zhang, Yan; Chen, Chun-Yuan; Liu, Yi-Wei; Rao, Shan-Shan; Tan, Yi-Juan; Qian, Yu-Xuan; Xia, Kun; Huang, Jie; Liu, Xi-Xi; Hong, Chun-Gu; Yin, Hao; Cao, Jia; Feng, Shi-Kai; He, Ze-Hui; Li, You-You; Luo, Zhong-Wei; Wu, Ben; Yan, Zi-Qi; Chen, Tuan-Hui; Chen, Meng-Lu; Wang, Yi-Yi; Wang, Zhen-Xing; Liu, Zheng-Zhao; Luo, Ming-Jie; Hu, Xiong-Ke; Jin, Ling; Wan, Teng-Fei; Yue, Tao; Tang, Si-Yuan; Xie, Hui.
Affiliation
  • Zhang Y; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Chen CY; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Liu YW; Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Rao SS; Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Tan YJ; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Qian YX; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Xia K; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Huang J; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Liu XX; Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Hong CG; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Yin H; Xiangya School of Nursing, Central South University, Changsha, Hunan, 410013, China.
  • Cao J; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Feng SK; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • He ZH; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Li YY; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Luo ZW; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Wu B; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Yan ZQ; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Chen TH; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
  • Chen ML; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Wang YY; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Wang ZX; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Liu ZZ; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Luo MJ; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Hu XK; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Jin L; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Wan TF; Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Yue T; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Tang SY; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Xie H; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Adv Sci (Weinh) ; 8(24): e2100808, 2021 12.
Article in En | MEDLINE | ID: mdl-34719888
ABSTRACT
A differentiation switch of bone marrow mesenchymal stem/stromal cells (BMSCs) from osteoblasts to adipocytes contributes to age- and menopause-associated bone loss and marrow adiposity. Here it is found that osteocytes, the most abundant bone cells, promote adipogenesis and inhibit osteogenesis of BMSCs by secreting neuropeptide Y (NPY), whose expression increases with aging and osteoporosis. Deletion of NPY in osteocytes generates a high bone mass phenotype, and attenuates aging- and ovariectomy (OVX)-induced bone-fat imbalance in mice. Osteocyte NPY production is under the control of autonomic nervous system (ANS) and osteocyte NPY deletion blocks the ANS-induced regulation of BMSC fate and bone-fat balance. γ-Oryzanol, a clinically used ANS regulator, significantly increases bone formation and reverses aging- and OVX-induced osteocyte NPY overproduction and marrow adiposity in control mice, but not in mice lacking osteocyte NPY. The study suggests a new mode of neuronal control of bone metabolism through the ANS-induced regulation of osteocyte NPY.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Osteoporosis / Bone and Bones / Neuropeptide Y / Adipocytes Limits: Animals Language: En Journal: Adv Sci (Weinh) Year: 2021 Document type: Article Affiliation country:
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Osteoporosis / Bone and Bones / Neuropeptide Y / Adipocytes Limits: Animals Language: En Journal: Adv Sci (Weinh) Year: 2021 Document type: Article Affiliation country: