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Molecular epidemiology of scrub typhus in Taiwan during 2006-2016.
Chen, Hsiang-Fei; Peng, Shih-Huan; Tsai, Kun-Hsien; Yang, Cheng-Fen; Chang, Mei-Chun; Hsueh, Yeou-Lin; Su, Chien-Ling; Wang, Ruo-Yu; Shu, Pei-Yun; Yang, Su-Lin.
Affiliation
  • Chen HF; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China.
  • Peng SH; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China.
  • Tsai KH; Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei, Republic of China.
  • Yang CF; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Republic of China.
  • Chang MC; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China.
  • Hsueh YL; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China.
  • Su CL; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China.
  • Wang RY; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China.
  • Shu PY; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China.
  • Yang SL; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China.
PLoS Negl Trop Dis ; 16(4): e0010369, 2022 04.
Article in En | MEDLINE | ID: mdl-35486655
ABSTRACT
Scrub typhus is the most common endemic vector-borne disease in Taiwan. We identified a total of 4,857 laboratory-confirmed cases during 2006-2016 with hyperendemic foci on offshore islands, including Penghu (778 cases, 16.0%) and Kinmen (716 cases, 14.7%), and eastern Taiwan, including Taitung (628 cases, 12.9%) and Hualien (508 cases, 10.5%). Scrub typhus cases occur year-round throughout Taiwan, with a summer peak in June and July. A total of 545 O. tsutsugamushi isolates were successfully obtained from patients infected in diverse geographic areas, including Taiwan and three offshore islands, and the complete open reading frame of the 56 kDa type-specific antigen gene (tsa56) sequence of these isolates was examined. High phylogenetic diversity was found in these isolates, which could be grouped into 36 distinct sequence types. Most isolates belonged to the Karp (49.9%; 272/545), followed by the TW-22 (17.8%; 97/454) and Kawasaki (14.7%; 80/545) genotypes. In conclusion, our data indicate the widespread presence of tsa56 genotypes closely related to Thailand and Korean strains and the presence of the unique endemic strains TW-12, TW-22, TW-29, and TW-36 in Taiwan.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Orientia tsutsugamushi / Scrub Typhus Type of study: Screening_studies Limits: Humans Country/Region as subject: Asia Language: En Journal: PLoS Negl Trop Dis Journal subject: MEDICINA TROPICAL Year: 2022 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Orientia tsutsugamushi / Scrub Typhus Type of study: Screening_studies Limits: Humans Country/Region as subject: Asia Language: En Journal: PLoS Negl Trop Dis Journal subject: MEDICINA TROPICAL Year: 2022 Document type: Article Affiliation country: