PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia.

Tsai, Hsiang-I; Wu, Yanping; Huang, Rui; Su, Dandan; Wu, Yingyi; Liu, Xiaoyan; Wang, Linglu; Xu, Zhanxue; Pang, Yuxin; Sun, Chong; He, Chao; Shu, Fan; Zhu, Haitao; Wang, Dongqing; Cheng, Fang; Huang, Laiqiang; Chen, Hongbo

Tsai, Hsiang-I; Wu, Yanping; Huang, Rui; Su, Dandan; Wu, Yingyi; Liu, Xiaoyan; Wang, Linglu; Xu, Zhanxue; Pang, Yuxin; Sun, Chong; He, Chao; Shu, Fan; Zhu, Haitao; Wang, Dongqing; Cheng, Fang; Huang, Laiqiang; Chen, Hongbo.

Affiliation

Tsai HI; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Wu Y; Department of Medical Imaging, the Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Huang R; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Su D; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.
Wu Y; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Liu X; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Wang L; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Xu Z; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Pang Y; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Sun C; School of Traditional Medicine Materials Resource, Guangdong Pharmaceutical University, Yunfu 527322, China.
He C; Immune Regulation in Cancer, German Cancer Research Center, Heidelberg 69120, Germany.
Shu F; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Zhu H; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Wang D; Department of Medical Imaging, the Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Cheng F; Department of Medical Imaging, the Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Huang L; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Chen H; The Shenzhen Key Lab of Gene and Antibody Therapy, Center for Biotechnology & Biomedicine, Division of Life and Health Sciences, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.

Acta Pharm Sin B ; 12(4): 1913-1927, 2022 Apr.

Article in En | MEDLINE | ID: mdl-35847518

Key words

AML; AML, acute myeloid; BFLS, BorjesonForssmanLehmann syndrome; CML, chronic myeloid leukemia; CX5461; ChIP, chromatin immunoprecipitation; Co-IP, co-immunoprecipitation; DFC, dense fibrillar component; Epigenetic; FC, fibrillar centers; FUrd, 5-fluorouridine; H3K27me1, histone H3 (mono-methyl K27); H3K27me2, histone H3 (di-methyl K27); H3K27me3, histone H3 (tri-methyl K27); H3K9me1, histone H3 (mono-methyl K9); H3K9me2, histone H3 (di-methyl K9); H3K9me3, histone H3 (tri-methyl K9); Leukemia; MPAL, mixed-phenotype acute leukemia; Methyltransferase; NLS, nuclear localization sequences; NoRC, nucleolar chromatin remodeling complex; NuRD, nucleosome remodeling and deacetylase; PHF6; PHF6, plant homeodomain-like finger protein 6; RNA Pol I, RNA polymerase I; Re-ChIP, double chromatin immunoprecipitation; SUV39H1; SUV39H1, suppressor of variegation 3-9 homolog 1; T-ALL, T-cell acute lymphoblastic leukemia; UBF1, upstream binding factor 1; pre-rRNA, pre-ribosme RNA; rDNA transcription; rDNA, ribosomal DNA; rRNA, ribosome RNA

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