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7-Methoxy-13-dehydroxypaxilline: New indole diterpenoid from an endophytic fungus Penicillium sp. Nb 19.
Yu, Jing; Wang, Jia-Peng; Liu, Shi-Fang; Yin, Cui-Yun; Tang, De-Ying; Li, Yi-Hang; Zhang, Li-Xia.
Affiliation
  • Yu J; Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, China.
  • Wang JP; Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical, College of Pharmacy, Dali University, Yunnan Dali, China.
  • Liu SF; Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, China.
  • Yin CY; Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, China.
  • Tang DY; Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, China.
  • Li YH; Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, China.
  • Zhang LX; Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, China.
Nat Prod Res ; 38(1): 103-111, 2024.
Article in En | MEDLINE | ID: mdl-35929965
ABSTRACT
ABSTACTA chemical investigation of the endophyte Penicillium sp. Nb 19, isolated from leaves of the traditionally medical plant Baphicacanthus cusia (Nees) Bremek., yielded one new indole diterpenoid, 7-methoxy-13-dehydroxypaxilline (1) together with seven known metabolites (2-8). The obtained structure of compound 1 was elucidated by its spectroscopic data. In addition, the absolute configuration of compound 6 was confirmed by ECD for the first time. Compounds 1-6 were evaluated for antitumor activity against MCF-7, HepG2, and HCCC-9810 cell lines.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillium / Diterpenes Language: En Journal: Nat Prod Res Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillium / Diterpenes Language: En Journal: Nat Prod Res Year: 2024 Document type: Article Affiliation country: Country of publication: