Lanostane triterpenoids from Ganoderma lucidum and their inhibitory effects against FAAH.
Phytochemistry
; 203: 113339, 2022 Nov.
Article
in En
| MEDLINE
| ID: mdl-35961409
ABSTRACT
Ganoderma lucidum is a famous edible and medicinal fungus. Through a bioactive phytochemical investigation of the ethanolic extracts of the fruiting bodies of G. lucidum, twenty-nine triterpenoids, including eleven previously undescribed triterpenoids, were isolated and characterized based on spectroscopic data. The inhibitory effects of all the triterpenes against fatty acid amide hydrolase (FAAH) were found to be in the range of 30-60% at 100 µM. Methyl ganoderate A displayed the strongest inhibitory activity (61%) against FAAH. Furthermore, all compounds displayed no cytotoxicity against LOVO and MCF-7 human cancer cells. Hence, our present study provides information about G. lucidum as a functional food or pharmaceutical supplement for the treatment of neuroinflammation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triterpenes
/
Reishi
/
Amidohydrolases
Limits:
Humans
Language:
En
Journal:
Phytochemistry
Year:
2022
Document type:
Article