DOG-1 positive primary acinic cell carcinoma of the lung and investigation of molecular status.
Pathologica
; 114(5): 385-390, 2022 Oct.
Article
in En
| MEDLINE
| ID: mdl-36305026
ABSTRACT
Primary acinic cell carcinoma (ACC) of the lung is an extremely rare neoplasm that more often arises near to a right bronchus. It is characterized by two populations of clear and dark eosinophilic cells, arranged in a glandular acinar pattern. Mitosis are rare and tumor cells show small and eccentric nuclei. Positive stain for PAS, PAS-D, cytokeratin, A1AT and A1ACT is reported, while TTF1, p40, synaptophysin, SMA, and S100 are substantially negative. DOG-1 positive stain was observed in ACC of the salivary glands and its negativity was proposed to distinguish between primary and metastatic ACC of the lung. Here, we report the 30th case of primary ACC of the lung, describing the immunohistochemical positivity for DOG-1 and the molecular status of the neoplasm for the first time.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salivary Gland Neoplasms
/
Carcinoma, Acinar Cell
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Pathologica
Year:
2022
Document type:
Article
Affiliation country: