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Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients.
Mhlanga, Adequate; Zakh, Rami; Churkin, Alexander; Reinharz, Vladimir; Glenn, Jeffrey S; Etzion, Ohad; Cotler, Scott J; Yurdaydin, Cihan; Barash, Danny; Dahari, Harel.
Affiliation
  • Mhlanga A; The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA.
  • Zakh R; Department of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel.
  • Churkin A; Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 84108, Israel.
  • Reinharz V; Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 84108, Israel.
  • Glenn JS; Department of Computer Science, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.
  • Etzion O; Division of Gastroenterology and Hepatology, Departments of Medicine, Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA.
  • Cotler SJ; Department of Gastroenterology and Liver Diseases, Soroka University Medical Center, Beer-Sheva 84101, Israel.
  • Yurdaydin C; The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA.
  • Barash D; Department of Gastroenterology and Hepatology, Koç University Medical School, Istanbul 34450, Turkey.
  • Dahari H; Department of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel.
Mathematics (Basel) ; 10(20)2022 Oct 02.
Article in En | MEDLINE | ID: mdl-36540372
ABSTRACT
Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mathematics (Basel) Year: 2022 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mathematics (Basel) Year: 2022 Document type: Article Affiliation country: