The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance.
Nat Commun
; 14(1): 6153, 2023 10 03.
Article
in En
| MEDLINE
| ID: mdl-37788991
ABSTRACT
Approximately 10% of antimicrobials used by humans in low- and middle-income countries are estimated to be substandard or falsified. In addition to their negative impact on morbidity and mortality, they may also be important drivers of antimicrobial resistance. Despite such concerns, our understanding of this relationship remains rudimentary. Substandard and falsified medicines have the potential to either increase or decrease levels of resistance, and here we discuss a range of mechanisms that could drive these changes. Understanding these effects and their relative importance will require an improved understanding of how different drug exposures affect the emergence and spread of resistance and of how the percentage of active pharmaceutical ingredients in substandard and falsified medicines is temporally and spatially distributed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Counterfeit Drugs
Limits:
Humans
Language:
En
Journal:
Nat Commun
Journal subject:
BIOLOGIA
/
CIENCIA
Year:
2023
Document type:
Article
Affiliation country: