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Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing.
Zhou, Yan; Guo, Yizhen; Ran, Maoxin; Shan, Wenying; Granchi, Carlotta; Giovannetti, Elisa; Minutolo, Filippo; Peters, Godefridus J; Tam, Kin Yip.
Affiliation
  • Zhou Y; Faculty of Health Sciences, University of Macau, Taipa, Macau.
  • Guo Y; Faculty of Health Sciences, University of Macau, Taipa, Macau.
  • Ran M; Faculty of Health Sciences, University of Macau, Taipa, Macau.
  • Shan W; Faculty of Health Sciences, University of Macau, Taipa, Macau.
  • Granchi C; Dipartimento di Farmacia, Università di Pisa, 56126, Pisa, Italy.
  • Giovannetti E; Department of Medical Oncology, Amsterdam University Medical Centers, Location VUmc, Cancer Center Amsterdam, 1081, HV Amsterdam, the Netherlands; Fondazione Pisana per La Scienza, Pisa, Italy.
  • Minutolo F; Dipartimento di Farmacia, Università di Pisa, 56126, Pisa, Italy.
  • Peters GJ; Department of Biochemistry, Medical University of Gdansk, 80-210, Gdansk, Poland; Department of Medical Oncology, Amsterdam University Medical Centers, Location VUmc, Cancer Center Amsterdam, 1081, HV Amsterdam, the Netherlands.
  • Tam KY; Faculty of Health Sciences, University of Macau, Taipa, Macau. Electronic address: kintam@um.edu.mo.
Cancer Lett ; 577: 216425, 2023 11 28.
Article in En | MEDLINE | ID: mdl-37805163
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma of Lung / Lactate Dehydrogenase 5 / Pyruvate Dehydrogenase Acetyl-Transferring Kinase / Lung Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cancer Lett Year: 2023 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma of Lung / Lactate Dehydrogenase 5 / Pyruvate Dehydrogenase Acetyl-Transferring Kinase / Lung Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cancer Lett Year: 2023 Document type: Article Affiliation country: Country of publication: