Bone marrow mesenchymal stem cellderived exosomes: A novel therapeutic agent for tendonbone healing (Review).
Int J Mol Med
; 52(6)2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-37937691
ABSTRACT
In sports medicine, injuries related to the insertion of tendons into bones, including rotator cuff injuries, anterior cruciate ligament injuries and Achilles tendon ruptures, are commonly observed. However, traditional therapies have proven to be insufficient in achieving satisfactory outcomes due to the intricate anatomical structure associated with these injuries. Adult bone marrow mesenchymal stem cells possess selfrenewal and multidirectional differentiation potential and can generate various mesenchymal tissues to aid in the recovery of bone, cartilage, adipose tissue and bone marrow hematopoietic tissue. In addition, extracellular vesicles derived from bone marrow mesenchymal stem cells known as exosomes, contain lipids, proteins and nucleic acids that govern the tissue microenvironment, facilitate tissue repair and perform various biological functions. Studies have demonstrated that bone marrow mesenchymal stem cellderived exosomes can function as natural nanocapsules for drug delivery and can enhance tendonbone healing strength. The present review discusses the latest research results on the role of exosomes released by bone marrow mesenchymal stem cells in tendonbone healing and provides valuable information for implementing these techniques in regenerative medicine and sports health.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Exosomes
/
Mesenchymal Stem Cells
/
Rotator Cuff Injuries
Limits:
Humans
Language:
En
Journal:
Int J Mol Med
Journal subject:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Year:
2023
Document type:
Article