Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophic <i>Salmonella</i> inhibited 4T1 breast tumors and metastasis in mice.

Sivasankar, Chandran; Hewawaduge, Chamith; Muthuramalingam, Pandiyan; Lee, John Hwa

Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophic Salmonella inhibited 4T1 breast tumors and metastasis in mice.

Sivasankar, Chandran; Hewawaduge, Chamith; Muthuramalingam, Pandiyan; Lee, John Hwa.

Affiliation

Sivasankar C; College of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea.
Hewawaduge C; College of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea.
Muthuramalingam P; Department of GreenBio Science, Gyeongsang National University, Jinju 52725, South Korea.
Lee JH; College of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea.

Mol Ther Nucleic Acids ; 34: 102053, 2023 Dec 12.

Article in En | MEDLINE | ID: mdl-37941832

Key words

4T1 breast cancer; MT: delivery strategies; RCAS1; Salmonella delivery; anti-tumor effect; antisense-RNA; tryptophan-auxotroph; tumor specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mol Ther Nucleic Acids Year: 2023 Document type: Article

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mol Ther Nucleic Acids Year: 2023 Document type: Article