Cellular and Molecular Connections Between Bone Fracture Healing and Exosomes.
Physiol Res
; 72(5): 565-574, 2023 11 28.
Article
in En
| MEDLINE
| ID: mdl-38015756
ABSTRACT
Fracture healing is a multifaceted process that requires various phases and intercellular interactions. In recent years, investigations have been conducted to assess the feasibility of utilizing exosomes, small extracellular vesicles (EVs), to enhance and accelerate the healing process. Exosomes serve as a cargo transport platform, facilitating intercellular communication, promoting the presentation of antigens to dendritic cells, and stimulating angiogenesis. Exosomes have a special structure that gives them a special function, especially in the healing process of bone injuries. This article provides an overview of cellular and molecular processes associated with bone fracture healing, as well as a survey of existing exosome research in this context. We also discuss the potential use of exosomes in fracture healing, as well as the obstacles that must be overcome to make this a viable clinical practice.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Exosomes
/
Mesenchymal Stem Cells
/
Extracellular Vesicles
Language:
En
Journal:
Physiol Res
Journal subject:
FISIOLOGIA
Year:
2023
Document type:
Article
Affiliation country: