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Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum.
Chery-Karschney, Laura; Patrapuvich, Rapatbhorn; Mudeppa, Devaraja Gouda; Kokkonda, Sreekanth; Chakrabarti, Rimi; Sriwichai, Patchara; O'Connor, Roberta M; Rathod, Pradipsinh K; White, John.
Affiliation
  • Chery-Karschney L; Department of Chemistry, University of Washington, Seattle, Washington, USA.
  • Patrapuvich R; Drug Research Unit for Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Mudeppa DG; Department of Chemistry, University of Washington, Seattle, Washington, USA.
  • Kokkonda S; Department of Chemistry, University of Washington, Seattle, Washington, USA.
  • Chakrabarti R; Department of Chemistry, University of Washington, Seattle, Washington, USA.
  • Sriwichai P; Department of Medicine, Goa Medical College and Hospital, Bambolim, Goa, India.
  • O'Connor RM; Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Rathod PK; Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • White J; Department of Chemistry, University of Washington, Seattle, Washington, USA.
Antimicrob Agents Chemother ; 68(2): e0068423, 2024 Feb 07.
Article in En | MEDLINE | ID: mdl-38193705
ABSTRACT
Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of Plasmodium falciparum at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Malaria, Falciparum / Artemisinins / Lactones / Antimalarials Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2024 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Malaria, Falciparum / Artemisinins / Lactones / Antimalarials Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2024 Document type: Article Affiliation country: