Interferon in the treatment of ill adults with Covid-19 in the Republic of Guinea.
Afr Health Sci
; 23(2): 43-55, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-38223582
ABSTRACT
Background:
Effective and safe antiviral treatments are required to refrain the COVID-19.Objectives:
Investigate the efficacy and safety of interferon in the treatment of COVID-19.Methods:
The inclusion criteria were patients who gave their signed consent, with detection confirmed by RT-PCR of SARS-CoV-2, 18 years and older. Patients received therapy as per the Guinea COVID-19 protocol in the group B; the group A received the same treatment including administration of interferon. The outcome measures the time to negative conversion of SARS-CoV-2, mortality, patients transferred to ICU and safety, according to the reports of adverse events.Results:
345 patients were included, 171 in the group A and 174 in the group B. After the treatments, the RT-PCR negative results were attained in the patients in the group A in 9.15±4.79 days and in those in the group B in 14.83±6.67 days. No patient in the group A had to be transferred to ICU, and they all survived; in the group B, 26 patients were transferred to ICU and six of them died. There were eight adverse events with causality relation with interferon administration.Conclusions:
The interferon resulted effective and safe in contributing to the viral replication conversion to negative results in shorter time and to survival.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Guideline
Limits:
Adult
/
Humans
Country/Region as subject:
Africa
Language:
En
Journal:
Afr Health Sci
Journal subject:
MEDICINA
/
SERVICOS DE SAUDE
Year:
2023
Document type:
Article
Affiliation country:
Country of publication: