Your browser doesn't support javascript.
loading
Programmed initiation and enhancement of cGAS/STING pathway for tumour immunotherapy via tailor-designed ZnFe2O4-based nanosystem.
Yang, Jing; He, Yuping; Zhang, Meng; Liang, Chenglin; Li, Tongtong; Ji, Tianjiao; Zu, Mali; Ma, Xu; Zhang, Zhenzhong; Liang, Chun; Zhang, Qixu; Chen, Youbai; Hou, Lin.
Affiliation
  • Yang J; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China.
  • He Y; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China.
  • Zhang M; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China.
  • Liang C; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China.
  • Li T; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China.
  • Ji T; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing China.
  • Zu M; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing China.
  • Ma X; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing China.
  • Zhang Z; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing China.
  • Liang C; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing China.
  • Zhang Q; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing China.
  • Chen Y; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences Zhengzhou University Zhengzhou China.
  • Hou L; Department of Plastic and Reconstructive Surgery Chinese PLA General Hospital Beijing China.
Exploration (Beijing) ; 3(6): 20230061, 2023 Dec.
Article in En | MEDLINE | ID: mdl-38264691
ABSTRACT
The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)/stimulator of interferon genes (STING) signalling pathway has been a promising target for anticancer immunity, but rationally activating and enhancing this pathway in tumour cells is critical. Herein, a glutathione sensitive ZnFe2O4-based nanosystem is developed to programmatically initiate and enhance the STING signalling pathway in tumour cells. The prepared ZnFe2O4 nanoparticles were coated with cancer cell membrane (CCM), which enabled the nanosystem target tumour cells. In tumour cells, ZnFe2O4 nanoparticles could be disintegrated by responding to high level glutathione, and the released Fe3+ generated reactive oxygen species to induce the DNA leakage into the cytoplasm to stimulate cGAS. Then Zn2+ promoted cGAS-DNA phase separation to intensify the cGAS enzymatic activity. In addition, the low dose encapsulation of paclitaxel (PTX) acting as an antimitotic agent (ZnFe2O4-PTX@CCM) ensured the sustained activation of cGAS/STING pathway. The in vitro and in vivo results confirmed that ZnFe2O4-PTX@CCM elevated the cGAS/STING activity, promoted dendritic cell maturation, increased cytotoxic T lymphocyte and natural killer cells infiltration, eventually inhibiting the tumour progress and postoperative recurrence. This study provided feasible references on constructing STING activation nanosystem for tumour immunotherapy.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Exploration (Beijing) Year: 2023 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Exploration (Beijing) Year: 2023 Document type: Article Country of publication: