[Effect of growth hormone supplementation on liver and lung function in patients with hypopituitarism].
Zhonghua Yi Xue Za Zhi
; 104(6): 450-452, 2024 Feb 06.
Article
in Zh
| MEDLINE
| ID: mdl-38326058
ABSTRACT
To analyze the clinical features of patients with anterior hypopituitarism (HP) complicated with cirrhosis, and to explore the effects of growth hormone supplementation on liver and lung function. A total of 11 patients with HP complicated with cirrhosis admitted to Peking Union Medical College Hospital from January 2016 to December 2022 were included in the study, including 8 males and 3 females, aged [M(Q1, Q3)]31 (20, 37) years. There were 6 patients with pituitary stalk interruption syndrome, 4 patients after craniopharyngioma resection, and 1 patient after germinal cell tumor chemoradiotherapy. Cirrhosis appeared at [M(Q1, Q3)]7 (1, 16) years after the diagnosis of HP. There were 7 cases complicated with hepatopulmonary syndrome (HPS). The liver and lung function of 5 patients were improved significantly after the addition of growth hormone, and the arterial partial pressure of oxygen increased from (47±11) mmHg(1 mmHg=0.133 kPa) to (84±12) mmHg. Timely supplementation of growth hormone can improve the symptoms of fatty liver, cirrhosis and HPS, and postpone or even avoid the transplantation of liver and other organs.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary Neoplasms
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Human Growth Hormone
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Hepatopulmonary Syndrome
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Hypopituitarism
Type of study:
Diagnostic_studies
Limits:
Aged
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Female
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Humans
/
Male
Language:
Zh
Journal:
Zhonghua Yi Xue Za Zhi
/
Zhonghua yi xue za zhi
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: