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Gram-negative endolysins: overcoming the outer membrane obstacle.
Sisson, Hazel M; Jackson, Simon A; Fagerlund, Robert D; Warring, Suzanne L; Fineran, Peter C.
Affiliation
  • Sisson HM; Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Bioprotection Aotearoa, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
  • Jackson SA; Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Bioprotection Aotearoa, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Maurice Wilkins Centre for Molecular Bio
  • Fagerlund RD; Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Bioprotection Aotearoa, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Maurice Wilkins Centre for Molecular Bio
  • Warring SL; Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
  • Fineran PC; Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Bioprotection Aotearoa, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Maurice Wilkins Centre for Molecular Bio
Curr Opin Microbiol ; 78: 102433, 2024 04.
Article in En | MEDLINE | ID: mdl-38350268
ABSTRACT
Our ability to control the growth of Gram-negative bacterial pathogens is challenged by rising antimicrobial resistance and requires new approaches. Endolysins are phage-derived enzymes that degrade peptidoglycan and therefore offer potential as antimicrobial agents. However, the outer membrane (OM) of Gram-negative bacteria impedes the access of externally applied endolysins to peptidoglycan. This review highlights recent advances in the discovery and characterization of natural endolysins that can breach the OM, as well as chemical and engineering approaches that increase antimicrobial efficacy of endolysins against Gram-negative pathogens.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteriophages / Anti-Infective Agents Language: En Journal: Curr Opin Microbiol Journal subject: MICROBIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteriophages / Anti-Infective Agents Language: En Journal: Curr Opin Microbiol Journal subject: MICROBIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication: