Autoimmune Movement Disorders Complicating Treatment with Immune Checkpoint Inhibitors.
Mov Disord Clin Pract
; 11(5): 543-549, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38400610
ABSTRACT
BACKGROUND:
Immune checkpoint inhibitors (ICI) may trigger autoimmune neurological conditions, including movement disorders (MD).OBJECTIVES:
The aim of this study was to characterize MDs occurring as immune-related adverse events (irAEs) of ICIs.METHODS:
A systematic literature review of case reports/series of MDs as irAEs of ICIs was performed.RESULTS:
Of 5682 eligible papers, 26 articles with 28 patients were included. MDs occur as a rare complication of cancer immunotherapy with heterogeneous clinical presentations and in most cases in association with other irAEs. Inflammatory basal ganglia T2/fluid attenuated inversion recovery abnormalities are rarely observed, but brain imaging is frequently unrevealing. Cerebrospinal fluid findings are frequently suggestive of inflammation. Half of cases are associated with a wide range of autoantibodies. Steroids and ICI withdrawal usually lead to improvement, even though some patients experienced relapses or a severe clinical course.CONCLUSION:
MDs are a rare complication of ICIs that should be promptly recognized to offer patients a correct diagnosis and treatment.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immune Checkpoint Inhibitors
/
Movement Disorders
Limits:
Humans
Language:
En
Journal:
Mov Disord Clin Pract
Year:
2024
Document type:
Article
Affiliation country: