Prognostic potency of plasma LRG1 measurement at multiple time points in acute ischemic stroke patients.
Biomark Med
; 18(5): 181-190, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38440887
ABSTRACT
Objective:
This study aimed to investigate the prognostic potency of LRG1 in acute ischemic stroke (AIS) patients.Methods:
Plasma LRG1 levels were detected at admission and on days 3, 7 and 30 in 150 AIS patients.Results:
LRG1 positively correlated with total cholesterol (p = 0.016), triglycerides (p = 0.046), C-reactive protein (p < 0.001), TNF-α (p = 0.001) and IL-6 (p = 0.004). After admission, LRG1 showed a decreasing trend (p < 0.001). Interestingly, LRG1 levels at admission (p = 0.014), day 3 (p = 0.027), day 7 (p = 0.008) and day 30 (p = 0.002) were higher in patients with modified Rankin scale score ≥2 versus those with scores <2. The LRG1 levels at day 7 (p = 0.032) and day 30 (p = 0.023) were higher in patients with recurrence versus no recurrence.Conclusion:
LRG1 correlates with blood lipids, inflammation and short-term prognosis of AIS.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stroke
/
Ischemic Stroke
Limits:
Humans
Language:
En
Journal:
Biomark Med
Journal subject:
BIOQUIMICA
/
MEDICINA
Year:
2024
Document type:
Article
Affiliation country: