The contribution of the donor vascularised hand and face allograft in transplant rejection: An immunological perspective.
Transpl Immunol
; 84: 102035, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38518826
ABSTRACT
Overcoming immunological rejection remains a barrier to the safe adoption of Vascularised Composite Allotransplantation (VCA). To mitigate this risk, clinical protocols have been derived from solid organ transplantation, targeting recipient immunomodulation, yet VCA is unique. Face and hand composite allografts are composed of multiple different tissues, each with their own immunological properties. Experimental work suggests that allografts carry variable numbers and populations of donor leukocytes in an organ specific manner. Ordinarily, these passenger leukocytes are transferred from the donor graft into the recipient circulation after transplantation. Whether alloantigen presentation manifests as acute allograft rejection or transplant tolerance is unknown. This review aims to characterise the immunological properties of the constituent parts of the donor face and hand, the potential fate of donor leukocytes and to consider theoretical graft specific interventions to mitigate early rejection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Facial Transplantation
/
Vascularized Composite Allotransplantation
/
Hand Transplantation
/
Graft Rejection
Limits:
Animals
/
Humans
Language:
En
Journal:
Transpl Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
/
TRANSPLANTE
Year:
2024
Document type:
Article
Country of publication: