Pioneering the Way: The Revolutionary Potential of Antibody-Drug Conjugates in NSCLC.
Curr Treat Options Oncol
; 25(4): 556-584, 2024 04.
Article
in En
| MEDLINE
| ID: mdl-38520605
ABSTRACT
OPINION STATEMENT Despite targeted therapy and immunotherapy being recognized as established frontline treatments for advanced non-small cell lung cancer (NSCLC), the unavoidable development of resistance and disease progression poses ongoing challenges. Antibody-drug conjugates (ADCs) offer a potent treatment option for NSCLC through the specific delivery of cytotoxic agents to tumor cells that display distinct antigens. This review delves into the latest evidence regarding promising ADC agents for NSCLC, focusing on their targets, effectiveness, and safety assessments. Additionally, our study provides insights into managing toxicities, identifying biomarkers, devising methods to counter resistance mechanisms, tackling prevailing challenges, and outlining prospects for the clinical implementation of these innovative ADCs and combination regimens in NSCLC.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Non-Small-Cell Lung
/
Immunoconjugates
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Lung Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Curr Treat Options Oncol
Journal subject:
NEOPLASIAS
Year:
2024
Document type:
Article
Affiliation country: