Proposed Framework for Research Case Definitions of Lipedema.
Lymphat Res Biol
; 22(2): 93-105, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38546398
ABSTRACT
Background:
Our aim is to propose a framework for the development of a research case definition of lipedema, based on current available literature and those observations that can be applied to future lipedema research with the intent to standardize and strengthen the scientific evidence base. Methods andResults:
We conducted a narrative review of the literature, and identified consensus characteristics and disputed characteristics that could be included in a research case definition of lipedema. After considering the strength of the evidence and how each characteristic might be measured in a research study, we recommended an approach for the development of a research case definition of lipedema that would be based on consideration of five agreed-upon characteristics, and five disputed, or less substantiated, characteristics as additional evidence to enhance specificity.Conclusions:
We present a case definition framework for lipedema drawn from the scientific literature that can be applied to future studies on lipedema. Utilizing this framework should help to increase the sensitivity and specificity of case definition and provide an opportunity for meta-analysis of clinical studies and facilitate future research intercomparisons.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lipedema
Limits:
Humans
Language:
En
Journal:
Lymphat Res Biol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: