Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression.
Exp Mol Med
; 56(4): 975-986, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38609519
ABSTRACT
We explored the genomic events underlying central neurocytoma (CN), a rare neoplasm of the central nervous system, via multiomics approaches, including whole-exome sequencing, bulk and single-nuclei RNA sequencing, and methylation sequencing. We identified FGFR3 hypomethylation leading to FGFR3 overexpression as a major event in the ontogeny of CN that affects crucial downstream events, such as aberrant PI3K-AKT activity and neuronal development pathways. Furthermore, we found similarities between CN and radial glial cells based on analyses of gene markers and CN tumor cells and postulate that CN tumorigenesis is due to dysregulation of radial glial cell differentiation into neurons. Our data demonstrate the potential role of FGFR3 as one of the leading drivers of tumorigenesis in CN.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neurocytoma
/
DNA Methylation
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Receptor, Fibroblast Growth Factor, Type 3
/
Ependymoglial Cells
Limits:
Humans
Language:
En
Journal:
Exp Mol Med
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Year:
2024
Document type:
Article
Country of publication: