Anxiety in Alzheimer's disease rats is independent of memory and impacted by genotype, age, sex, and exercise.
Alzheimers Dement
; 20(5): 3543-3550, 2024 05.
Article
in En
| MEDLINE
| ID: mdl-38624069
ABSTRACT
INTRODUCTION:
Alzheimer's disease (AD) is characterized by cognitive impairments; however, heightened anxiety often accompanies and, in some cases, exacerbates cognitive its. The present study aims to understand the influence of multiple variables on anxiety-like behavior in TgF344-AD rats and determine whether anxiety impacts memory performance.METHODS:
An elevated plus maze was used to assess anxiety-like behavior in the established colony (n = 107). Influences of age, sex, genotype, and exercise on anxiety were evaluated via multiple linear regression. Correlation analysis evaluated the relationship between anxiety and memory performance.RESULTS:
Age (P < 0.05) and AD genotype (P < 0.001) were associated with increasing anxiety, while exercise (P < 0.05) was associated with decreasing anxiety. Female AD animals displayed more anxiety-like behavior versus wild-type female (P < 0.001) and AD male (P < 0.05) littermates.DISCUSSION:
Concluding that while factors such as age, sex, AD genotype, and training status can impact anxiety levels in the TgF344-AD model, anxiety level did not impact memory performance. HIGHLIGHTS Increased anxiety-like behavior in TgF344-AD rats does not correlate with declines in memory performance. Predictors of higher anxiety-like behaviors in the TgF344-AD rat include age, Alzheimer's disease (AD) genotype, and sex with female AD animals experiencing greater anxiety compared to female wild-type or male AD. Exercise training leads to decreased anxiety-like behaviors in the TgF344-AD rat.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anxiety
/
Physical Conditioning, Animal
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Disease Models, Animal
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Rats, Transgenic
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Alzheimer Disease
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Genotype
Limits:
Animals
Language:
En
Journal:
Alzheimer's & dementia
/
Alzheimers Dement
/
Alzheimers dememt
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: