The Tip of the Iceberg: Genotype of Puerto Rican Pediatric Obesity.
Genes (Basel)
; 15(4)2024 03 22.
Article
in En
| MEDLINE
| ID: mdl-38674329
ABSTRACT
Childhood obesity is a significant public health concern, particularly among Hispanic populations. This study aimed to elucidate the genetic predisposition to obesity in Puerto Rican children of Hispanic descent, addressing a notable gap in existing research. A cohort of 103 children with obesity and hyperphagia underwent genetic screening for rare obesity-related variants. Clinical assessments and family history evaluations were conducted to characterize the demographic and clinical characteristics of the cohort. Genetic testing revealed a high prevalence of variants, with 73% of subjects having at least one reported variant. Pathogenic variants, predominantly associated with obesity-related ciliopathies, were identified in 7% of cases. Additionally, 90% of cases had variants of uncertain significance, highlighting the complexity of genetic contributions to obesity. This study emphasizes the critical need for further investigation into the genetic foundations of obesity, particularly within Hispanic communities. The findings emphasize the importance of early medical evaluation, vigilant monitoring for hyperphagia onset, and targeted interventions tailored to the unique genetic landscape of Puerto Rican children. This research provides a foundational framework for future studies to mitigate the impact of genetic obesity within this population.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hispanic or Latino
/
Genetic Predisposition to Disease
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Pediatric Obesity
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Country/Region as subject:
Caribe
/
Puerto rico
Language:
En
Journal:
Genes (Basel)
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: