Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers.
Methods Mol Biol
; 2806: 41-53, 2024.
Article
in En
| MEDLINE
| ID: mdl-38676795
ABSTRACT
Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold standard for evidence-based preclinical research in pediatric neuro-oncology. This protocol describes the generation of PDOX models by intracranial implantation of human pediatric brain cancer cells into immune-deficient mice, and their continued propagation to establish cohorts of animals for preclinical research.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Disease Models, Animal
Limits:
Animals
/
Child
/
Humans
Language:
En
Journal:
Methods Mol Biol
/
Methods in molecular biology
/
Methods mol. biol
Journal subject:
BIOLOGIA MOLECULAR
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: