Your browser doesn't support javascript.
loading
Heart Failure with Normal Natriuretic Peptide Levels and Preserved Ejection Fraction: A Prospective Clinical and Cardiac MRI Study.
He, Jian; Yang, Wenjing; Wu, Weichun; Yin, Gang; Zhuang, Baiyan; Xu, Jing; Zhou, Di; Zhang, Jian; Wang, Yining; Zhu, Leyi; Sun, Xiaoxin; Sirajuddin, Arlene; Teng, Zhongzhao; Kureshi, Faraz; Arai, Andrew E; Zhao, Shihua; Lu, Minjie.
Affiliation
  • He J; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Yang W; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Wu W; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Yin G; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Zhuang B; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Xu J; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Zhou D; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Zhang J; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Wang Y; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Zhu L; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Sun X; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Sirajuddin A; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Teng Z; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Kureshi F; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Arai AE; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Zhao S; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
  • Lu M; From the Department of Magnetic Resonance Imaging (J.H., W.Y., G.Y., B.Z., J.X., D.Z., Y.W., L.Z., S.Z., M.L.), Department of Echocardiography (W.W.), Heart Failure Center (J.Z.), and Department of Nuclear Medicine (X.S.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy
Radiol Cardiothorac Imaging ; 6(3): e230281, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38695743
ABSTRACT
Purpose To describe the clinical presentation, comprehensive cardiac MRI characteristics, and prognosis of individuals with predisposed heart failure with preserved ejection fraction (HFpEF). Materials and Methods This prospective cohort study (part of MISSION-HFpEF [Multimodality Imaging in the Screening, Diagnosis, and Risk Stratification of HFpEF]; NCT04603404) was conducted from January 1, 2019, to September 30, 2021, and included individuals with suspected HFpEF who underwent cardiac MRI. Participants who had primary cardiomyopathy and primary valvular heart disease were excluded. Participants were split into a predisposed HFpEF group, defined as HFpEF with normal natriuretic peptide levels based on an HFA-PEFF (Heart Failure Association Pretest Assessment, Echocardiography and Natriuretic Peptide, Functional Testing, and Final Etiology) score of 4 from the latest European Society of Cardiology guidelines, and an HFpEF group (HFA-PEFF score of ≥ 5). An asymptomatic control group without heart failure was also included. Clinical and cardiac MRI-based characteristics and outcomes were compared between groups. The primary end points were death, heart failure hospitalization, or stroke. Results A total of 213 participants with HFpEF, 151 participants with predisposed HFpEF, and 100 participants in the control group were analyzed. Compared with the control group, participants with predisposed HFpEF had worse left ventricular remodeling and function and higher systemic inflammation. Compared with participants with HFpEF, those with predisposed HFpEF, whether obese or not, were younger and had higher plasma volume, lower prevalence of atrial fibrillation, lower left atrial volume index, and less impaired left ventricular global longitudinal strain (-12.2% ± 2.8 vs -13.9% ± 3.1; P < .001) and early-diastolic global longitudinal strain rate (eGLSR, 0.52/sec ± 0.20 vs 0.57/sec ± 0.15; P = .03) but similar prognosis. Atrial fibrillation occurrence (hazard ratio [HR] = 3.90; P = .009), hemoglobin level (HR = 0.94; P = .001), and eGLSR (per 0.2-per-second increase, HR = 0.28; P = .002) were independently associated with occurrence of primary end points in participants with predisposed HFpEF. Conclusion Participants with predisposed HFpEF showed relatively unique clinical and cardiac MRI features, warranting greater clinical attention. eGLSR should be considered as a prognostic factor in participants with predisposed HFpEF. Keywords Heart Failure with Preserved Ejection Fraction, Normal Natriuretic Peptide Levels, Cardiovascular Magnetic Resonance, Myocardial Strain, Prognosis Clinical trial registration no. NCT04603404 Supplemental material is available for this article. © RSNA, 2024.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stroke Volume / Natriuretic Peptides / Heart Failure Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Radiol Cardiothorac Imaging Year: 2024 Document type: Article Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stroke Volume / Natriuretic Peptides / Heart Failure Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Radiol Cardiothorac Imaging Year: 2024 Document type: Article Country of publication: