The Chinese keratoconus (CKC) cohort study.
Eur J Epidemiol
; 39(6): 679-689, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38703249
ABSTRACT
The Chinese keratoconus (CKC) cohort study is a population-based longitudinal prospective cohort study in the Chinese population involving a clinical database and biobanks. This ongoing study focuses on the prevention of KC progression and is the first to involve the effect of geneâenvironment interactions on KC progression. The CKC cohort is hospital-based and dynamic and was established in Zhengzhou, China; KC patients (n = 1114) from a large geographical area were enrolled from January 2019 to June 2023, with a mean age of 22.23 years (6â57 years). Demographic details, socioeconomic characteristics, lifestyle, disease history, surgical history, family history, and visual and social function data are being collected using questionnaires. General physical examination, eye examination, biological specimen collection, and first-degree relative data were collected and analyzed in the present study. The primary focus of the present study was placed on gene, environment and the effect of geneâenvironment interactions on KC progression. The follow-up of the CKC cohort study is expected to include data collection at 3 months, 6 months, and 1 year after the initial examination and then at the annual follow-up examinations. The first follow-up of the CKC cohort study was recorded. A total of 918 patients completed the follow-up by June 1, 2023, with a response rate of 82.40%. Aside from the younger age of patients who were followed up, no significant differences were found between patients who were followed up and patients who were not.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene-Environment Interaction
/
Keratoconus
Limits:
Adolescent
/
Adult
/
Child
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Female
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Humans
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Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Eur J Epidemiol
Journal subject:
EPIDEMIOLOGIA
Year:
2024
Document type:
Article
Affiliation country: