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Generation of a human induced pluripotent stem cell line (YUCMi020-A) from peripheral blood mononuclear cells derived from a female with the Jr(a-) blood type.
Cho, Youn Keong; Kim, Hyun-Kyung; Suh, Eun Jung; Kim, Hyun Ok; Kim, Sinyoung.
Affiliation
  • Cho YK; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim HK; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Suh EJ; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim HO; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim S; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: sykim@yuhs.ac.
Stem Cell Res ; 77: 103434, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38703667
ABSTRACT
The Jra antigen, the only antigen within the JR blood group system, is a high-prevalence red blood cell (RBC) antigen found in over 99 % of the global population. An induced pluripotent stem cell line (YUCMi020-A) was generated from peripheral blood drawn from a Jr(a-) phenotype individual, who was homozygous for a null mutation of ABCG2*01N.01 (rs72552713, c.376C>T; p.Gln126*). The generated line exhibited pluripotent characteristics and no chromosomal aberrations. This cell line will serve as a cell source, enabling us to produce RBCs with the Jr(a-) phenotype in vitro, which can be used for transfusing individuals with anti-Jra antibodies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukocytes, Mononuclear / Induced Pluripotent Stem Cells Limits: Female / Humans Language: En Journal: Stem Cell Res / Stem cell research (Online) Year: 2024 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukocytes, Mononuclear / Induced Pluripotent Stem Cells Limits: Female / Humans Language: En Journal: Stem Cell Res / Stem cell research (Online) Year: 2024 Document type: Article Country of publication: