Nivalones CF, four new meroterpenoids from Rhododendron nivale.
Fitoterapia
; 176: 106017, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38740343
ABSTRACT
Four new meroterpenoids, namely nivalones CF (1-4), along with a known meroterpenoid, cannabiorcicyclolic acid (5), were isolated from the branches and leaves of Rhododendron nivale. The chemical structures of compounds 1-4 were elucidated through comprehensive spectroscopic analyses, including NMR, UV-Vis, IR, ECD spectroscopy, as well as HR-ESI-MS. The isolated compounds were evaluated for their anti-inflammatory and neuroprotective properties. The inhibitory activity of compound 5 against lipopolysaccharide (LPS)-induced nitric oxide (NO) production was initially demonstrated, showcasing an IC50 value of 21.1 µM. Additionally, both compounds 2 and 5 displayed a notable effect on the viability of H2O2-damaged SH-SY5Y cells, indicating their significant neuroprotection effects.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Terpenes
/
Plant Leaves
/
Neuroprotective Agents
/
Rhododendron
/
Phytochemicals
/
Anti-Inflammatory Agents
/
Nitric Oxide
Limits:
Animals
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Fitoterapia
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: