Treatment of primary cardiac diffuse large B-cell lymphoma involving the coronary sinus with R-EPOCH: a case report and literature review.
Ann Hematol
; 103(7): 2557-2560, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38748259
ABSTRACT
Primary cardiac lymphomas (PCLs) are a rare clinical entity, in which treatment guidelines remain to be established. Rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (R-EPOCH) has been proposed, given that it involves a continuous infusion of anthracycline, reducing the risk of a cardiotoxicity and therefore the theoretical risk of perforation. However, the literature on this method of treatment is scarce. Herein, we present a unique case of a 75-year-old male, diagnosed with primary cardiac diffuse large B-cell lymphoma (DLBCL) with relatively unusual involvement of the coronary sinus, treated first with one cycle of R-EPOCH, followed by three cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) to reduce said risk. To our knowledge, this is one of two cases, in which a patient with PCL was treated this way.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vincristine
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Prednisone
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Antineoplastic Combined Chemotherapy Protocols
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Doxorubicin
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Lymphoma, Large B-Cell, Diffuse
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Cyclophosphamide
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Etoposide
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Coronary Sinus
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Rituximab
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Heart Neoplasms
Limits:
Aged
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Humans
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Male
Language:
En
Journal:
Ann Hematol
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Ann. hematol
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Annals of hematology
Journal subject:
HEMATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: