Infection as a trigger of acute, transient glomerular deposition of clonal immunoglobulins.
Ultrastruct Pathol
; 48(4): 304-309, 2024 Jul 03.
Article
in En
| MEDLINE
| ID: mdl-38752567
ABSTRACT
Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typically associated with plasma cell or B-lymphoid neoplasms, particularly lymphoplasmacytic lymphoma (LPL). While infection is a frequent trigger of mixed (type II and III) CG, its association with type I CG is uncommon. We report two cases in which striking lambda-chain-restricted IgM deposits and acute kidney injury (AKI) occurred in the setting of known or suspected systemic infections, with prompt resolution on treatment of the infection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin M
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Acute Kidney Injury
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Kidney Glomerulus
Limits:
Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Ultrastruct Pathol
Year:
2024
Document type:
Article
Affiliation country: