Two new jatrophane diterpenoids from Euphorbia helioscopia with activity towards autophagic flux.
J Asian Nat Prod Res
; 26(8): 900-909, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38753580
ABSTRACT
Nine jatrophane diterpenoids were isolated from the whole plant Euphorbia helioscopia, including two new ones, helioscopnins A (1) and B (2). Comprehensive spectroscopic data analysis and ECD calculations elucidated their structures, including absolute configurations. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds 1, 3, 4, 5, 8, and 9 significantly increased autophagic flux.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Euphorbia
/
Diterpenes
Limits:
Humans
Language:
En
Journal:
J Asian Nat Prod Res
Journal subject:
BOTANICA
/
QUIMICA
Year:
2024
Document type:
Article
Affiliation country: