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(G)Patching up mis-splicing in cancer.
Ciesla, Maciej; Bellodi, Cristian.
Affiliation
  • Ciesla M; IMol Polish Academy of Sciences, Warsaw, Poland.
  • Bellodi C; Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Faculty of Medicine, Lund University, 22184 Lund, Sweden. Electronic address: cristian.bellodi@med.lu.se.
Trends Biochem Sci ; 49(7): 564-566, 2024 Jul.
Article in En | MEDLINE | ID: mdl-38762373
ABSTRACT
Benbarche, Pineda, Galvis, et al. delineate an essential role for the G-patch motif-containing protein GPATCH8 in mis-splicing associated with cancer-driving mutations of the splicing factor SF3B1. GPATCH8 cooperates with SF3B1 mutants, affecting the splicing machinery. Targeting GPATCH8 reveals therapeutic opportunities for SF3B1 mutant cancers and other splicing-related diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Splicing / RNA Splicing Factors / Neoplasms Limits: Humans Language: En Journal: Trends Biochem Sci Year: 2024 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Splicing / RNA Splicing Factors / Neoplasms Limits: Humans Language: En Journal: Trends Biochem Sci Year: 2024 Document type: Article Affiliation country: