(G)Patching up mis-splicing in cancer.
Trends Biochem Sci
; 49(7): 564-566, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38762373
ABSTRACT
Benbarche, Pineda, Galvis, et al. delineate an essential role for the G-patch motif-containing protein GPATCH8 in mis-splicing associated with cancer-driving mutations of the splicing factor SF3B1. GPATCH8 cooperates with SF3B1 mutants, affecting the splicing machinery. Targeting GPATCH8 reveals therapeutic opportunities for SF3B1 mutant cancers and other splicing-related diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA Splicing
/
RNA Splicing Factors
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Trends Biochem Sci
Year:
2024
Document type:
Article
Affiliation country: