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Atramacrolodes A-D (1-4), Four Undescribed Eudesmane-type Sesquiterpenes from the Rhizome of Atractylodes macrocephala.
Li, Chuang-Jun; Li, Bei; Tian, Yulu; Guo, Xinyi; Ren, Yating; Ma, Jie; Zang, Yingda; Sun, Hua; Zhang, Dongming.
Affiliation
  • Li CJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Medicinal chemistry, 1 Xian Nong Tan Street　, Not Available, 100050, Beijing, CHINA.
  • Li B; Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.
  • Tian Y; Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.
  • Guo X; Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.
  • Ren Y; Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.
  • Ma J; Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.
  • Zang Y; Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.
  • Sun H; Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.
  • Zhang D; Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.
Chem Biodivers ; : e202400817, 2024 May 22.
Article in En | MEDLINE | ID: mdl-38775105
ABSTRACT
Four undescribed sesquiterpenes, atramacrolodes A-D (1-4), along with six known compounds 5-10 were isolated from the rhizome of Atractylodes macrocephala. Compound 3 possessed a new skeleton based on an unprecedented carton-carton connection. Their structures were determined by UV, IR, HRESIMS, NMR spectra, 13C NMR calculation with DP4+ analysis, and the comparison of experimental and calculated ECD spectra. Compounds 5 and 8 showed protective effects against paracetamol-induced liver cell injury.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Document type: Article Affiliation country: